Hodgkin Disease
《Hodgkin Disease》專家PPT內(nèi)容預(yù)覽
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《Hodgkin Disease》專家PPT內(nèi)容簡介
Definition:
neoplastic disorder with development of specific infiltrate containing pathologic Reed-Sternberg cells. It usually arises in lymph nodes and spreads to contiguous groups. Extranodal presentation are rare. Disease is associated with defective cellular immunity.
Incidence:
- 2-4 cases per 100000 population / year
- bimodal age distribution :
15-35 years and above 50 years
- male predominance M:F = 1,7:1
Clinical Presentation
Nontender lymph nodes enlargement ( localised )
neck and supraclavicular area 60-80%
mediastinal adenopathy 50%
other ( abdominal, extranodal disease )
systemic symptoms (B symptoms) 30%
fever
night sweats
unexplained weight loss (10% per 6 months)
other symptoms
fatigue, weakness, pruritus
cough , chest pain, shortness of breath, vena cava syndrome
abdominal pain, bowel disturbances, ascites
bone pain
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